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Roger F Butterworth Selected Research

GABA-A Receptors (GABA(A) Receptor)

1/2016Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities.
7/2012Reduced brain levels of DHEAS in hepatic coma patients: significance for increased GABAergic tone in hepatic encephalopathy.
9/2006Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
12/2005Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy.
7/2005Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
5/2005Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.
12/2004Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy.
11/2003Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy.
8/2003Molecular neurobiology of acute liver failure.
5/2002Mitochondrial dysfunction in acute hyperammonemia.

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Roger F Butterworth Research Topics

Disease

36Hepatic Encephalopathy
06/2021 - 05/2002
34Acute Liver Failure (Fulminant Hepatic Failure)
12/2016 - 08/2002
31Brain Edema (Cerebral Edema)
12/2016 - 07/2002
29Brain Diseases (Brain Disorder)
12/2016 - 08/2002
25Hypothermia
12/2016 - 12/2002
23Liver Failure
12/2016 - 07/2002
17Coma (Comas)
07/2012 - 07/2002
15Hyperammonemia
01/2019 - 05/2002
12Fibrosis (Cirrhosis)
06/2021 - 01/2003
10Thiamine Deficiency
01/2021 - 07/2004
10Inflammation (Inflammations)
02/2019 - 04/2005
10Liver Diseases (Liver Disease)
01/2019 - 01/2003
9End Stage Liver Disease
07/2009 - 08/2002
6Neuroinflammatory Diseases
12/2016 - 04/2011
5Wernicke Encephalopathy (Wernicke's Encephalopathy)
12/2010 - 12/2003
4Sarcopenia
06/2021 - 06/2014
4Malnutrition (Nutritional Deficiencies)
03/2015 - 12/2003
4Intracranial Hypertension
06/2012 - 12/2005
3Parkinson Disease (Parkinson's Disease)
09/2021 - 09/2002
3Parkinsonian Disorders (Parkinsonism)
02/2019 - 06/2013
3Stroke (Strokes)
08/2014 - 12/2004
3Nervous System Diseases (Neurological Disorders)
03/2014 - 09/2003
3Infections
06/2013 - 11/2008
3Lactic Acidosis
03/2008 - 01/2005
3Gliosis
12/2003 - 06/2002
3Inborn Urea Cycle Disorders
09/2003 - 08/2002
3Reye Syndrome (Reye's Syndrome)
09/2003 - 08/2002
2Neurodegenerative Diseases (Neurodegenerative Disease)
09/2021 - 12/2003
2Cognitive Dysfunction
09/2021 - 08/2014
2Hemorrhage
01/2020 - 01/2010
2Necrosis
01/2012 - 11/2008

Drug/Important Bio-Agent (IBA)

37AmmoniaIBA
06/2021 - 05/2002
22Proteins (Proteins, Gene)FDA Link
01/2019 - 08/2002
16Glutamic Acid (Glutamate)FDA Link
12/2016 - 06/2002
15CytokinesIBA
12/2016 - 12/2007
14Messenger RNA (mRNA)IBA
03/2014 - 06/2002
12NeurosteroidsIBA
02/2019 - 08/2002
12Thiamine (Aneurin)FDA Link
01/2014 - 12/2003
11Glutamine (L-Glutamine)FDA Link
01/2019 - 12/2002
10ornithylaspartateIBA
06/2021 - 12/2002
10Neurotransmitter Agents (Neurotransmitter)IBA
02/2019 - 08/2002
10Amino AcidsFDA Link
01/2019 - 12/2002
10GABA-A Receptors (GABA(A) Receptor)IBA
01/2016 - 05/2002
9EnzymesIBA
01/2019 - 05/2002
9Minocycline (Cyclops)FDA LinkGeneric
03/2015 - 04/2009
9Lactic Acid (Lactate)FDA LinkGeneric
09/2013 - 02/2003
9Glucose (Dextrose)FDA LinkGeneric
12/2008 - 12/2002
8ManganeseIBA
02/2019 - 01/2003
7AntioxidantsIBA
12/2016 - 12/2009
7Acetylcysteine (Siran)FDA LinkGeneric
09/2013 - 10/2007
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2016 - 11/2008
6N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
12/2016 - 05/2002
6Etanercept (Enbrel)FDA Link
03/2015 - 11/2011
6salicylhydroxamic acid (SHAM)IBA
12/2009 - 12/2002
5Interleukin-6 (Interleukin 6)IBA
12/2016 - 11/2011
5AlbuminsIBA
12/2016 - 01/2006
5InterleukinsIBA
12/2016 - 11/2008
5Anti-Bacterial Agents (Antibiotics)IBA
03/2015 - 12/2002
5Anti-Inflammatory Agents (Anti-Inflammatories)IBA
03/2015 - 04/2009
5BenzodiazepinesIBA
06/2006 - 11/2003
4Urea (Carbamide)FDA LinkGeneric
06/2021 - 07/2002
4Glutathione (Reduced Glutathione)IBA
01/2019 - 01/2007
4Lactulose (Duphalac)FDA LinkGeneric
12/2016 - 07/2010
4Protein Isoforms (Isoforms)IBA
09/2014 - 07/2004
4Biological ProductsIBA
08/2014 - 08/2003
4Pregnanolone (Allopregnanolone)IBA
07/2012 - 11/2003
4AzoxymethaneIBA
06/2010 - 05/2006
4Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA
03/2009 - 05/2002
4gamma-Aminobutyric Acid (GABA)IBA
07/2008 - 02/2003
4LigandsIBA
09/2006 - 08/2002
3Aspartic Acid (Aspartate)FDA Link
01/2019 - 09/2003
3Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA
12/2016 - 06/2006
3Rifaximin (L 105)FDA Link
12/2016 - 02/2011
3Cysteine (L-Cysteine)FDA Link
12/2016 - 06/2013
3ZincIBA
03/2015 - 04/2005
3Dietary ProteinsIBA
09/2014 - 12/2007
3Glial Fibrillary Acidic ProteinIBA
03/2014 - 06/2002
3Pharmaceutical PreparationsIBA
03/2014 - 04/2009
3SteroidsIBA
07/2010 - 07/2005
3Acetaminophen (Paracetamol)FDA LinkGeneric
06/2010 - 01/2007
3OccludinIBA
10/2009 - 07/2009
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2008 - 03/2003
3PregnenoloneIBA
03/2008 - 05/2005
3Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2004 - 11/2002
2GABA Receptors (GABA Receptor)IBA
02/2019 - 12/2004
2MetalsIBA
12/2016 - 07/2010
2octanoic acid (caprylic acid)IBA
12/2016 - 11/2008
2Riboflavin (Vitamin B2)FDA LinkGeneric
03/2015 - 06/2014
2Vitamin A (Retinol)FDA LinkGeneric
03/2015 - 06/2014
2NeurotoxinsIBA
09/2014 - 01/2003
2Immunoglobulin G (IgG)IBA
03/2014 - 10/2009
2Excitatory Amino AcidsIBA
03/2014 - 06/2002
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2014 - 10/2009
2Indomethacin (Indometacin)FDA LinkGeneric
04/2011 - 10/2007
2Caveolin 1IBA
12/2010 - 07/2009
2Interleukin-1beta (Interleukin 1 beta)IBA
01/2010 - 04/2005

Therapy/Procedure

8Liver Transplantation
03/2015 - 01/2003
6Therapeutics
03/2015 - 12/2002
5Ligation
07/2009 - 08/2002
4Surgical Portacaval Shunt (Portacaval Anastomosis)
07/2009 - 08/2002